Table 3.
Pneumococcal Serotypes in patients with SIgMD with specific antibody deficiency
| S. pneumococcal Serotypes | All Patients | IgM < 30 mg/dL | IgM > 30 mg/dL |
|---|---|---|---|
| # (%) patients with unprotected titers* and/or impaired response | # (%) patients with unprotected titers* and/or impaired response | # (%) patients with unprotected titers* and/or impaired response | |
| 1 | 18 (67%) | 4 (50%) | 14 (74%) |
| 2 | 5 (19%) | 2 (25%) | 3 (16%) |
| 3 | 21 (78%) | 7 (88%) | 14 (74%) |
| 4 | 26 (96%) | 8 (100%) | 18 (95%) |
| 5 | 13 (48%) | 4 (50%) | 9 (47%) |
| 26 (6B) | 16 (59%) | 5 (63%) | 11 (58%) |
| 51 (7F) | 17 (63%) | 6 (75%) | 11 (58%) |
| 8 | 15 (56%) | 5 (63%) | 10 (53%) |
| 68 (9V) | 19 (70%) | 7 (88%) | 12 (63%) |
| 9 (9N) | 21 (78%) | 6 (75%) | 15 (79%) |
| 34 (10A) | 8 (30%) | 3 (38%) | 5 (26%) |
| 43 (11A) | 6 (22%) | 3 (38%) | 3 (16%) |
| 12 (12F) | 23 (85%) | 7 (88%) | 16 (84%) |
| 17 (17F) | 8 (30%) | 2 (25%) | 6 (32%) |
| 14 | 12 (44%) | 5 (63%) | 7 (37%) |
| 19 (19F) | 16 (59%) | 4 (50%) | 12 (63%) |
| 20 | 3 (11%) | 2 (25%) | 1 (5%) |
| 22 (22F) | 10 (37%) | 4 (50%) | 6 (32%) |
| 23 (23F) | 22 (81%) | 6 (75%) | 15 (79%) |
| 54 (15B) | 6 (22%) | 3 (38%) | 3 (16%) |
| 56 (18C) | 12 (44%) | 4 (50%) | 8 (42%) |
| 57 (19A) | 4 (15%) | 3 (38%) | 1 (5%) |
| 70 (33F) | 8 (30%) | 3 (38%) | 5 (26%) |
*
Unprotected titers were serotypes with <1.3 μg/dl, Impaired response was <2 fold increase in post vaccination titers from baseline 34/62=55% patients with Specific Antibody Deficiency Reported in chart, but no supporting pre and post serotypes available 10 of 13 (77%) with lgM <30 mg/dl had low response to Pneumovax-23.