Figure 6.

A MUC1 epitope displayed on Qβ phage reduces tumor load in mice. (a) A peptide of MUC1 selected through phage‐mediated epitope discovery was conjugated to the surface of Qβ phage and injected into MUC1 transgenic mice. (b) When the mice were also challenged with B16‐MUC1 cells, lung metastases were significantly reduced in immunized mice. (c) Qβ‐MUC1 administered along with a checkpoint blockade resulted in reduced growth of solid tumors. Adapted with permission from Wu X, Yin Z, McKay C, et al. Protective epitope discovery and design of MUC1‐based vaccine for effective tumor protections in immunotolerant mice. J Am Chem Soc. 2018;140(48):16596–16609. Copyright 2018 American Chemical Society100