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. 2019 Nov 11;69(2):215–227. doi: 10.2337/db19-0061

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© 2019 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Diabetes remission after immunomodulation and infusion of antigen-specific T_regs in recently diabetic NOD mice. A: Experimental scheme. B: Percentage of diabetic mice after αCD3, CyP, and/or IAC immunomodulation and adoptive transfer of antigen-specific T_regs isolated from BDC2.5 TCR NOD mice into recently diabetic NOD mice. Diabetic mice were initially given a single insulin pellet at the start of αCD3 treatment to control diabetes. Urine and blood glucose levels were monitored for 6 months after the start of αCD3 treatment. Median values are indicated to the right of the legends. C: Percentage of skin graft survival of NOD and B6 skin placed 6 months after the start of αCD3 and BDC2.5 T_reg infusion. Mice were monitored for skin rejection and diabetes development for 70 days. Inset shows blood glucose values for the transplanted mice. Survival curves were subjected to Mantel-Cox log-rank test. The P value is indicated on the graph. d, day; UD, undefined.