Table 4.
Adjusted ORs of type 2 diabetes and adjusted βs of HbA1c with each additional copy of the MTNR1B G risk allele across categories of morningness-eveningness preference
| Type 2 diabetes | HbA1c (mmol/mol) | |||||
|---|---|---|---|---|---|---|
| Type 2 diabetes case/control subjects, n/n | OR (95% CI) | Pint | N | β (95% CI) | Pint | |
| Overall (n = 169,926) | 4,519/165,407 | 1.10 (1.04–1.15) | 0.044 | 157,256 | 0.26 (0.23–0.29) | 0.87 |
| Definite morning | 1,272/42,097 | 1.17 (1.07–1.28) | 39,976 | 0.30 (0.25–0.36) | ||
| More morning than evening | 1,482/60,064 | 1.09 (1.00–1.18) | 57,127 | 0.23 (0.19–0.28) | ||
| More evening than morning | 1,268/48,593 | 1.06 (0.97–1.16) | 46,267 | 0.23 (0.18–0.28) | ||
| Definite evening | 497/14,653 | 1.02 (0.88–1.18) | 13,886 | 0.36 (0.27–0.45) | ||
Association results are adjusted ORs (95% CI) of type 2 diabetes per each additional copy of the MTNR1B G risk allele or adjusted βs (95% CI) describing differences in HbA1c in mmol/mol per each additional copy of the MTNR1B G risk allele across categories of morningness-eveningness preference. Association analyses are adjusted for age, sex, BMI, genotyping array, and 10 principal components of ancestry. Pint is log likelihood ratio test comparing models with and without cross-product interaction terms (MTNR1B and morningness-eveningness preference) including main effect terms in logistic or linear regression models adjusted for the aforementioned covariates.