Fig.5.

2a and 2b pre-treatment ameliorate ATP levels, mitochondrial respiration (RCR) and cell survival after oxidative insult in control (Co) and APP cells. Co and APP cells were pre-treated with the TSPO ligand 2b or 2a for 24 h and then exposed to H₂O₂ (500 μM for 3 h). H₂O₂ treatment induces a decrease of the ATP level, RCR as well as the cell survival both cell lines. The TSPO ligand 2b or 2a improved the ATP level, RCR and cell survival. Values represent the mean±SEM; n = 4–6 replicates of three independent experiments normalized to Co or APP cells treated with H₂O₂. One-way ANOVA and post hoc Dunnett’s multiple comparison test versus Co or APP cells treated with H₂O₂, ^*p < 0.05, ^**p < 0.0001, ^***p < 0.001.