Fig.1.

Genetic factors and molecular mechanisms of oxidative stress in Alzheimer’s disease. Overview of probable (experimental evidence available in literature) and possible (no direct experimental evidence available) genetic factors that associate oxidative stress with Alzheimer’s disease. Various molecular mechanisms by which oxidative stress and Alzheimer’s disease may be associated have been described. These often involve the two hallmark proteins Aβ and tau and effects may be directly involving the generation of ROS or indirectly via interaction with various cellular factors giving rise to increased ROS generation or lowered endogenous antioxidant capacity.