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. 2020 Jan 20;15:7. doi: 10.1186/s13020-020-0288-z

Table 5.

Key articles in each cluster

Cluster Coverage TGCS Title First author Journal Year
0 14 34 Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study LIU, L Naunyn-Schmiedebergs Archives of Pharmacology 2010
1 13 17 Pharrnacokinetic properties, potential herb-drug interactions and acute toxicity of oral rhizoma coptidis alkaloids MA, BL Expert Opinion on Drug Metabolism & Toxicology 2013
2 10 30 Protoberberine alkaloids: physicochemical and nucleic acid binding properties., V10, P55 10.1007/7081_2007_071 MAITI, M Bioactive Heterocycles IV Topics in Heterocyclic Chemistry 2007
3 5 226 A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of turkish berberis species KUPELI, E Life Sciences 2002
4 9 4 Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly YI, CM Chemical Communications 2017
5 7 13 Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine SUZUKI, H Biological & Pharmaceutical Bulletin 2010
6 7 28 Involvement of mitochondrial and b-raf/erk signaling pathways in berberine-induced apoptosis in human melanoma cells BURGEIRO, A Anti-Cancer Drugs 2011
7 9 23 Role of berberine in alzheimer’s disease CAI, ZY Neuropsychiatric Disease and Treatment 2016
8 5 121 Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1 beta and inducible nitric oxide synthase in the rat model of alzheimer’s disease ZHU, FQ BMC Neuroscience 2006
9 5 80 Berberine, a plant alkaloid with lipid- and glucose-lowering properties: from in vitro evidence to clinical studies PIRILLO, A Atherosclerosis 2015
10 7 10 Blockade of l-type calcium channel in myocardium and calcium-induced contractions of vascular smooth muscle by cpu 86017 DAI, DZ Acta Pharmacologica Sinica 2004
11 3 54 Coptidis rhizoma: protective effects against peroxynitrite-induced oxidative damage and elucidation of its active components YOKOZAWA, T Journal of Pharmacy and Pharmacology 2004