Table 2.
Characteristics* of the patients successfully genotyped (N = 57)
| Category | Parameters | Characteristics | Total [N (% or IQR)] | #P-Values |
|---|---|---|---|---|
| Demographics | Sex | Female | 39 (68) | 0.042 |
| Male | 18 (32) | |||
| Age at baseline | Median (IQR) years | 34 (30–42) | 0.921 | |
| Marital Status | Single | 12 (21) | 0.663 | |
| Married | 29 (51) | |||
| Divorced/Separated | 4 (7) | |||
| Widowed | 12 (21) | |||
| Education | None | 6 (11) | 0.770 | |
| Primary | 14 (25) | |||
| Secondary | 18 (32) | |||
| Tertiary | 19 (33) | |||
| Occupation | Not Employed | 15 (26) | 0.338 | |
| Employed | 42 (74) | |||
| Clinical Parameters | First-line Backbone NRTI | AZT | 34 (60) | 0.978 |
| TDF | 16 (28) | |||
| bOthers | 7 (12) | |||
| First-line Second NRTI | 3TC | 39 (68) | 0.666 | |
| FTC | 18 (32) | |||
| First-line NNRTI | NVP | 43 (75) | 0.071 | |
| EFV | 14 (25) | |||
| Time on First-line ART (Months) | ART Initiation to F1 | 21 (12–36) | 0.217 | |
| F1 to FC | 5 (4–6) | 0.086 | ||
| FC to Viral Re-suppression | 5 (3–10) | 0.118 | ||
| Laboratory Parameters | Baseline CD4+ cells/μL | < 200 | 38 (67) | 0.780 |
| 200–350 | 17 (30) | |||
| > 350 | 2 (4) | |||
| Median (IQR) | 155 (105–235) | |||
| Baseline Viral Load (VL), copies/mL | ≤100,000 | 36 (63) | 0.774 | |
| > 100,000 | 18 (32) | |||
| Unknown | 3 (5) | |||
| Median (IQR) | 43,587 (13128–176,990) | |||
| VL at initial failure (copies/mL) | Median (IQR) | 9113 (3680–49,670) | 0.768 | |
| VL at confirmatory failure (copies/mL) | Median (IQR) | 16,266 (2042–4,002,513) | 0.454 | |
| HIV-1 Subtype | G | 25 (44) |
0.261 Grouped as G, CRF02_AG and Others |
|
| CRF02_AG | 23 (40) | |||
| A | 3 (5) | |||
| CRF06_cpx | 3 (5) | |||
| J | 1 (2) | |||
| C | 1 (2) | |||
| Recombinant of A1, G | 1 (2) |
aDemographic characteristics of those successfully genotyped were not significantly different from those not genotyped; F1 First VL ≥ 1000 cp/mL; FC Second VL ≥ 1000 cp/mL. #P-value is for difference in patient characteristic and drug resistance. IQR Interquartile range. bOthers = Backbone NRTI was switched