Table 2.
Treatments and disease characteristics of ESPOIR RA patients 1-year post-inclusion
| All RA patients (n = 487) | HCMV seropositive RA patients (n = 273) (56%) | HCMV seronegative RA patients (n = 214) (44%) | p (HCMV+ versus HCMV−) | |
|---|---|---|---|---|
| Patients with DMARD, n (%) | 417/458 (91.05) | 237/262 (90.5) | 180/196 (91.8) | 0.6090 |
| Use of csDMARD, n (%) | 376/458 (82.10) | 210/262 (80.15) | 166/196 (84.70) | 0.2100 |
| Use of bDMARD, n (%) | 41/458 (8.95) | 27/262 (10.31) | 14/196 (7.14) | 0.2410 |
| Delay between inclusion and first DMARD (months), median (IQR) | 0.38 (0.03–1.20) | 0.39 (0.03–1.22) | 0.36 (0.07–1.38) | 0.5225 |
| Patients with glucocorticoids at baseline, n (%) | 0 (0) | 0 (0) | 0 (0) | – |
| Cumulated dose of glucocorticoids between inclusion and 1 year in milligram, median (IQR) | 210 (0–2120) | 646 (0–2217) | 100 (0–1935) | 0.1393 |
| Total Sharp score (mTSS), median (IQR) | 4 (1–10) | 4 (1–9) | 4 (1–10) | 0.8913 |
| Delta total Sharp score (0–1 year), mean (SD)* | 1.70 (4.49) | 1.29 (3.38) | 2.22 (5.57) | 0.0238 |
| Delta total Sharp score (0–1 year), median (IQR) | 0 (0–1) p95 = 11 | 0 (0–1) p95 = 9 | 0 (0–2) p95 = 13 | 0.0349 |
| OR [95% CI] = 0.623 [0.464–1.005] | 0.0540 | |||
| Delta Sharp total score (0–1 year) > 1, n (%)* | 103 (21.2) | 47 (17.2)* | 56 (26.3) | 0.0151 |
| OR [95% CI] = 0.583 [0.367–0.925] | 0.0151 | |||
| Joint space narrowing Sharp score (NSS), median (IQR) | 1 (0–5) | 1 (0–5) | 1 (0–4) | 0.9121 |
| Delta joint space narrowing Sharp score (0–1 year), mean (SD) | 0.26 (1.16) | 0.24 (1.17) | 0.29 (1.14) | 0.6992 |
| Delta joint space narrowing Sharp score (0–1 year), median (IQR) | 0 (0–0) p95 = 2 | 0 (0–0) p95 = 1 | 0 (0–0) p95 = 2 | 0.4129 |
| OR [95% CI] = 0.763 [0.378–1.541] | 0.4129 | |||
| Joint space narrowing Sharp score (0–1 year), Δ > 1, n (%) | 26/486 (5.3) | 13 (4.8) | 13 (6.1) | 0.5140 |
| OR [95% CI] = 0.769 [0.321–1.846] | 0.5140 | |||
| Erosion Sharp score (ESS), median (IQR) | 2 (0–5) | 2 (0–5) | 2 (0–6) | 0.9588 |
| Delta erosion Sharp score (0–1 year), mean (SD)* | 1.43 (3.82) | 1.05 (2.63) | 1.93 (4.90) | 0.0112 |
| Delta erosion Sharp score (0–1 year), median (IQR)* | 0 (0–1) p95 = 9 | 0 (0–1) p95 = 8* | 0 (0–2) p95 = 12 | 0.0172 |
| OR [95% CI] = 0.637 [0.432–0.939] | 0.0230 | |||
| Erosion Sharp score (0–1 year), Δ > 1, n (%)* | 98 (20.1) | 44 (16.1)* | 54 (25.2) | 0.0128 |
| OR [95% CI] = 0.569 [0.355–0.911] | 0.0128 | |||
* p < 0.05