Table 2.
GDM risk factors according to disease status and Odds Ratios (ORs) in two cohorts
| Variables | Exploratory cohort (n = 3956) | External validation cohort (n = 6572) | ||||
|---|---|---|---|---|---|---|
| Crude OR (95% CI) | Adjusted OR (95%CI) | P | Crude OR (95% CI) | Adjusted OR (95%CI) | P | |
| Age, years | 1.11 (1.08–1.14) | 1.09 (1.06–1.11) | < 0.0001 | 1.12 (1.09–1.14) | 1.01 (1.07–1.12) | < 0.0001 |
| Pre-BMI, kg/m2 | 1.18 (1.14–1.22) | 1.13 (1.09–1.17) | < 0.0001 | 1.17 (1.13–1.21) | 1.11 (1.08–1.15) | < 0.0001 |
| Family history | 1.89 (1.57–2.26) | 1.64 (1.36–1.98) | < 0.0001 | 2.19 (1.81–2.66) | 1.93 (1.58–2.35) | < 0.0001 |
| FPG | 3.28 (2.62–4.11) | 2.60 (2.07–3.27) | < 0.0001 | 3.47 (2.77–4.34) | 2.77 (2.20–3.48) | < 0.0001 |
| parity | 1.49 (1.22–1.81) | 1.14 (0.91–1.43) | 0.266 | 1.32 (1.12–1.56) | 0.89 (0.74–1.07) | 0.216 |
Based on multiple logistic regression models adjusted mutually
OR odds ratio, pre-BMI pre-pregnancy body mass index, FPG fasting plasma glucose