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. 2020 Jan 20;12:16. doi: 10.1186/s13148-020-0811-1

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — CpG sites with methylation differences between the two ER-positive BRCA subgroups. a Percentage of hypermethylated and hypomethylated sites between hypo-ER-positive and hyper-ER-positive cancer subgroups. b Survival curve in the two subgroups based on the methylation level of the 2772 hypo-DMCs. c Distribution of hypo-DMCs in various genomic sequences. d Genes with hypo-DMCs enriched in pathways related with cancer