Table 1.
Comparison of features between NMOSD patients of SSM group and LETM group.
| SSM group (n = 12) | LETM group (n = 34) | p value | |
|---|---|---|---|
| Age of onset, years, Median (range) | 58 (43–79) | 50.5 (19–81) | 0.271 |
| Female-to-male ratio | 2:1 | 7.5:1 | 0.178 |
| Time to baseline MRI, days, Median (range) | 15 (3–28) | 8 (1–28) | 0.249 |
| EDSS score at nadir of first attack, Median (range) | 2 (1–7.5) | 3.75 (1–8.5) | 0.045 |
| Delayed in diagnosis,* no. (%) | 4/12 (33%) | 1/34 (3%) | 0.013 |
| CSF white cell count (/μl), Median (range) | 5.5 (2–30) | 7 (1–160) | 0.566 |
| CSF protein (mg/dl), Median (range) | 34.8 (19.2–51.5) | 48.65 (26.3–138.3) | 0.006 |
| CSF oligoclonal bands, no. (%) | 0/7 (0%) | 0/15 (0%) | – |
| Positive serum autoimmune antibodies, no. (%) | 9/12 (75%) | 25/34 (74%) | 1.000 |
| Co-existing systemic autoimmune disease, no. (%) | 1/12 (8%) | 5/34 (15%) | 1.000 |
CSF, cerebrospinal fluid; EDSS, Expanded Disability Status Scale; LETM, longitudinally extensive transverse myelitis; MRI, magnetic resonance imaging; NMOSD, neuromyelitis optica spectrum disorder; SSM, short segment myelitis.
*
Delayed in diagnosis was defined as failure in making the NMOSD diagnosis during the hospitalization for the first myelitis attack.