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. 2020 Jan 20;28:7. doi: 10.1186/s12998-019-0293-4

Table 5.

Correlation coefficients for changes from baseline between cardiovascular autonomic outcomes and PPT in an RCT on spinal manipulation

Outcomes Log local PPT (kPa) N = 41 Distal PPT (kPa) N = 37
Post 1 − Baseline Post 2 − Baseline Post 3 − Baseline Post 1 − Baseline Post 2 − Baseline Post 3 − Baseline
RRi (ms) SM − 0.021 − 0.003 0.012 − 0.332 − 0.071 0.097
N = 41 Sham − 0.237 − 0.168 − 0.098 0.014 − 0.065 0.103
Log HF-HRV (ms2) SM − 0.212 0.073 − 0.034 − 0.067 0.007 0.070
N = 41 Sham − 0.124 − 0.028 − 0.184 − 0.038 − 0.062 0.047
HF normalized unit SM − 0.266 − 0.049 − 0.058 − 0.037 − 0.013 0.211
N = 41 Sham − 0.087 0.065 − 0.167 − 0.308 − 0.026 − 0.300
Log LF-HRV (ms2) SM 0.120 0.126 0.077 − 0.012 − 0.015 − 0.127
N = 41 Sham − 0.010 − 0.205 0.134 0.220 − 0.020 0.451
Log LF/HF SM 0.296 0.045 0.116 0.056 − 0.020 − 0.200
N = 41 Sham 0.079 − 0.083 0.219 0.262 0.036 0.376
Log RMSSD (ms) SM − 0.204 0.161 0.086 − 0.102 0.015 0.046
N = 41 Sham − 0.139 − 0.006 − 0.191 − 0.142 − 0.041 0.074
Log SDNN (ms) SM − 0.188 0.077 − 0.081 − 0.001 0.114 − 0.024
N = 41 Sham − 0.160 − 0.041 − 0.263 − 0.062 − 0.145 − 0.024
SBP (mmHg) SM 0.141 0.081 0.087 0.209 0.137 0.343
N = 30 Sham 0.165 0.247 0.336 0.412 0.509 0.581
DBP (mmHg) SM − 0.010 − 0.022 0.015 − 0.094 0.097 0.024
N = 30 Sham 0.153 0.094 0.190 0.020 0.343 0.266
MBP (mmHg) SM 0.040 0.012 0.046 − 0.052 0.156 0.165
N = 30 Sham 0.149 0.138 0.187 0.058 0.428 0.380
LF-SBP (mm2Hg) SM 0.278 0.142 0.164 0.062 0.007 − 0.236
N = 30 Sham 0.181 − 0.038 0.090 0.379 0.043 0.058

Notes

- Statistically significant correlations at p < 0.006 (Bonferroni correction) are bold faced

- † Spearman’s correlation coefficients

- Pearson’s correlation coefficients unless contrary mention

- For correlations between blood pressure and distal PPT results were based (i) on 27 subjects for Post 1 - Baseline and Post 2 - Baseline and (ii) on 25 subjects for Post 3 - Baseline

Abbreviations:

SM Spinal manipulation, RRi intervals between normal beats; Log logarithm with base 10; HF high frequency; HF normalized unit: HF/(HF + LF)×100; LF low frequency; RMSSD root mean square of the successive differences between normal heartbeats; SDNN standard deviation of the inter beat interval of normal sinus beats; SBP systolic blood pressure; DBP diastolic blood pressure; MBP mean blood pressure; PPT pressure pain threshold in kilopascal