Fig. 4.

Regulatory motifs potentially operative in individual cells of the brain. A) Expression levels (FPKMs) of Cebpa and Jun in astrocytes (Astro), neurons (Neuro), oligodendrocyte precursor cells (OPCs), newly formed oligodendrocytes (NFOs), myelinating oligodendrocytes (MYOs), microglia (Micro), and endothelial cells (Endot). Colors indicate Cebpa (sky blue) and Jun (dark blue), respectively. B) Radar plots showing expression levels (FPKMs) of target genes regulated by Cebpa-Jun pair in the indicated cells. Different colors were used to distinguish the cell types. C) Log₂-fold-changes of target genes regulated by the Cebpa-Jun pair in the B6-RML combination. Colors indicate Cebpa (sky blue), Jun (dark blue), and targets (gray). D) Pearson correlation coefficients between log₂-fold-changes of Cebpa and Jun (left bar) and distributions of Pearson correlation coefficients of log₂-fold-changes of their target genes with those of Cebpa (sky blue boxplot) or Jun (dark blue boxplot). F) Core TF pairs that could be operative in each cell type, which were highlighted in yellow