Table 4.
Laboratory findings of patients with monomicrobial necrotizing fasciitis by gram-negative pathogen and gram-positive pathogen
| Variable | Gram-negative pathogen (n = 55) | Gram-positive pathogen (n = 45) | P-value |
|---|---|---|---|
| Total WBCa count | |||
| Leukocytosis (≧ 12,000/uL) | 28 (50.9) | 31 (68.9) | 0.069 |
| Leukopenia (≦ 4000/uL) | 4 (7.3) | 2 (4.4) | 0.554 |
| Leukocytosis or Leukopenia | 32 (58.2) | 33 (73.3) | 0.114 |
| Differential count | |||
| Band forms > 3% | 29 (52.7) | 14 (31.1) | 0.030* |
| Neutrophilia (> 7500/uL) | 38 (69.1) | 35 (77.8) | 0.330 |
| Lymphocytopenia (< 1000/uL) | 34 (61.8) | 23 (51.1) | 0.282 |
| Hemoglobin (< 10 g/dL) | 9 (16.4) | 4 (8.9) | 0.269 |
| Thrombocytopenia (< 15 × 104/uL) | 29 (52.7) | 18 (40.0) | 0.205 |
| Hypoalbuminemia (< 2.5 g/dL) | 7 (12.7) | 1 (2.2) | 0.054 |
| Hyperlactatemia (> 20 mg/dL) | 35 (63.6) | 7 (15.6) | < 0.001* |
| C-reactive protein (< 150 mg/L) | 40 (72.7) | 17 (37.8) | < 0.001* |
| Creatinine (μmol/L) | 180.4 ± 137.2 | 134.5 ± 109.7 | 0.072 |
| D-dimer (mg/L) | 4.3 ± 6.9 | 2.6 ± 5.8 | 0.222 |
| Fibrinogen (mg/dL) | 316.5 ± 145.8 | 517.4 ± 164.5 | < 0.001* |
| Glucose (mmol/L) | 9.7 ± 6.4 | 10.3 ± 5.2 | 0.647 |
| Sodium (mmol/L) | 135.5 ± 3.5 | 135.0 ± 3.5 | 0.544 |
| LRINECb score≧6 | 18 (32.7) | 28 (62.2) | 0.003* |
| PTc (seconds) | 13.4 ± 4.9 | 11.0 ± 2.0 | 0.003* |
| Total bilirubin (mg/dL) | 1.9 ± 1.9 | 1.7 ± 3.9 | 0.718 |
Data was presented as mean (standard deviation) or frequency (%)
Abbreviations: aWBC White blood cell, bLRINEC Laboratory risk indicator for necrotizing fasciitis, cPT Prothrombin time
*: p-value < 0.05