Table 3.
Differences in characteristics between individual quadrants at baseline
| “Can’t do, don’t do” vs “Can do, don’t do” | “Can’t do, don’t do” vs “Can’t do, do do” | “Can’t do, don’t do” vs “Can do, do do” | “Can do, don’t do” vs “Can’t do, do do” | “Can do, don’t do” vs “Can do, do do” | “Can’t do, do do” vs “Can do, do do” | |
|---|---|---|---|---|---|---|
| Age, y | −1 (− 3/2) | −8 (− 11/− 4)* | 1 (− 3/1) | −7 (− 10/− 4)* | 0 (− 2/2) | 7 (3/10)* |
| mMRC score, N | − 1 (− 1/− 1)* | 0 (− 1/0) | − 1 (− 2/− 1)* | 1 (0/1) | 0 (− 1/0)* | − 1 (− 2/0)* |
| CAT score, N | − 4.3 (−6.1/− 2.4)* | −0.14 (− 4.0/3.7) | −4.6 (− 6.7/− 2.6)* | 4.1 (0.6/7.6) | −0.4 (− 2.4/1.6) | −4.5 (− 8.9/− 0.1) |
| Depression score, N | −2 (− 3/− 1)* | −1 (− 3/2) | − 2 (− 3/− 1)* | 1 (−1/4) | 0 (− 1/1) | −1 (− 4/1) |
| FEV1, % pred. | 13 (8/18)* | 7 (−2/20) | 23 (17/30)* | −5 (−15/5) | 9 (3/16)* | 15 (6/25) |
| RV/TLC, % | −7 (− 10.9/− 4.0)* | −7 (− 14/0) | − 11 (− 14/− 8)* | 0 (−7/7) | − 4 (− 8/0) | − 4 (− 11/3) |
| TLco, % pred. | 11 (6/17)* | 6 (−2/15) | 25 (18/31)* | −5 (− 16/4) | 12 (5/18)* | 18.5 (8/28)* |
| Number of comorbidities, N | −1 (− 1/0) | −2 (− 2/− 1)* | − 1 (− 2/− 1)* | −1 (− 2/0)* | −1 (− 1/0)* | 1 (0/1) |
| Exacerbations in the previous year, N | 0 (−1/0) | 0 (− 1/1) | − 1 (− 1/0)* | 1 (0/2) | 0 (0/0) | − 1 (− 2/0)* |
| Severe exacerbations in the previous year, N | 0 (0/0)* | 0 (0/0) | 0 (0/0)* | 0 (0/0) | 0 (0/0) | 0 (0/0) |
| Survival time, days (N = 214) | 332 (49/698) | 884 (328/1358) | 732 (386/1075)* | 461 (− 181/1069) | 303 (62/568)* | −84 (− 701/467) |
| 6MWD, m | 169.0(182.8/195.2)* | 35.2 (−13.2/83.7) | 210.7 (185.5/236.0)* | − 133.8 (− 184.4/83.2)* | 41.7 (15.6/67.8) | 175.5 (123.8/227.2)* |
| 6MWD, % pred. | 32 (28/36)* | 2 (− 3/8) | 40 (36/44)* | −29 (− 36/− 22)* | 7 (3/12) | 37 (31/44)* |
| SpO2 after 6MWT, % | 2 (0/5)* | 4 (1/7) | −4 (2/7)* | 1 (−1/4) | 2 (4/1) | 1 (−2/3) |
| Steps per day, N | 692 (263/1108) | 4770 (3716/6145)* | 5193 (4657/5822)* | 3990 (2916/5641)* | 4477 (3939/5130)* | 349 (− 627/1508) |
Values are median (95% CI). *p-value < 0.05. mMRC modified medical research council, CAT COPD assessment test, FEV1 forced expiratory volume in one second, RV/TLC residual volume to total lung capacity ratio, TLco diffusing capacity of the lung for carbon monoxide, 6MWD 6-min walking distance, SaO2 oxygen saturation