Table 4.
Comparison of median annual change in clinical characteristics between changing groups
| Dependent variable | Remainer N = 100 | Decliner N = 29 | Improver N = 20 | Waverer N = 24 | P-value |
|---|---|---|---|---|---|
| Median annual change BMI, kg/m2 | −0.08 (− 0.75/0.66) | − 0.03 (− 1.09/0.46) | 0.01 (− 0.93/1.02) | 0 (− 0.71/0.35) | 0.740 |
| Median annual change Waist/Hip ratio | 0.01 (− 0.03/0.04) | 0.01 (− 0.01/0.03) | −0.01 (− 0.03/0.02) | 0 (− 0.04/0.02) | 0.094 |
| Median annual change mMRC score | 0 (0/1) | 0 (0/1) | 0 (− 1/0) | 0 (0/1) | 0.210 |
| Median annual change CAT score | 1 (−3/3) | 2 (−2/4) | −1 (− 5/3)† | 1 (− 2/3)‡ | 0.042 |
| Median annual change Anxiety score | 0 (− 2/1) | 0 (− 1/1) | 0 (− 2/1) | 0 (− 1/2) | 0.330 |
| Median annual change Depression score | 0 (−2/1) | 0 (− 1/2) | − 1 (− 2/0) † | 0.5 (− 1.0/1.5) | 0.045 |
| Median annual change FEV1, % pred. | 0 (−4/6) | 0 (− 3/5) | 3 (− 4/6) | − 2 (− 6/1)* | 0.046 |
| Median annual change RV/TLC, % | 0 (−5/5) | 1 (− 5/5) | 0 (− 3.0/2.5) | 2.5 (− 2.5/6.0) | 0.180 |
| Median annual change TLco, % pred. | −2 (− 6.7/4.0) | − 3 (−9/2) | 0 (− 6/6) | − 1.0 (− 7.0/5.0) | 0.400 |
| Median annual change PaO2, kPa | 0.1 (− 0.7/0.6) | −0.21 (− 0.69/0.60) | −0.20 (− 0.82/0.56) | 0.08 (− 0.82/0.75) | 0.840 |
| Median annual change PaCO2, kPa | 0 (− 0.31/0.23) | 0.01 (− 0.27/0.20) | −0.10 (− 0.29/0.14) | 0.02 (− 0.17/0.42) | 0.450 |
| Median annual change SaO2, % | 0 (− 1.1/1.2) | 0.1 (− 1.5/1.0) | −0.2 (− 1.5/1.0) | 0 (− 1/1) | 0.860 |
| Median annual change Number of comorbidities | 0 (0/0) | 0 (0/1) | 0 (0/1) | 0 (0/0) | 0.100 |
| Median annual change Exacerbations in the previous year, N | 0 (− 1/0) | 0 (− 1/1) | 0 (−0.5/0.0) | 0 (− 1/1) | 0.850 |
| Median annual change Severe exacerbations in the previous year, N | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0.810 |
| Median annual change 6MWD, m | 0 (− 30/30) | −25 (− 60.0/28.7) | 11 (− 18/57.5)† | 0 (−75/35) | 0.019 |
| Median annual change 6MWD, % pred. | 1.5 (− 3.0/10.0) | 0 (−11/7) | 9.5 (−2/20) | 1 (− 14/14)‡ | 0.005 |
| Median annual change SpO2 after 6MWT, % | 0 (−3/3) | −1 (− 3/2) | 0 (− 3/2) | −1 (− 5/4) | 0.540 |
| Median annual change Steps per day, N | − 298 (− 1418/566) | − 1202 (− 2926/− 348)* | − 192 (− 1393/1809)† | − 761 (− 1870/665) | < 0.001 |
Values are median (25%/75% quartiles). *p < 0.05 vs “remainer”; †p < 0.05 vs “worsener”; ‡p < 0.005 vs “improver”