High resolution respirometry of permeabilised vastus medialis biopsies from MHN (n= 36) and MHS (n=23) individuals. Boxplots show median, inter-quartile range (IQR) and min-max range for each phenotype in control and halothane-exposed samples. Statistically significant pairwise comparisons (P<0.05) are labelled with an asterisk (refer to Table 2 for exact P-values). CI, complex I; CII, complex II; CIV, complex IV; ETS, electron transport system; MHN, malignant hyperthermia-negative; MHS, malignant hyperthermia-susceptible; OXPHOS, oxidative phosphorylation.