Table 2.
Summary of statistical comparisons for each data set, outlining P-values for each pairwise comparison between and within phenotype for the mass-specific oxygen flux (pmol s−1 mg−1) and flux control ratio (FCR) readings. The P-values for FCR differences between MHS subgroups are also included with post hoc statistics for each comparison. P-values reaching statistical significance are presented in bold font. ETS, electron transport system; MHN, malignant hyperthermia-negative; MHS, malignant hyperthermia-susceptible; MHSh, abnormal response in the in vitro contracture test to halothane but not caffeine; MHShc, abnormal response in the in vitro contracture test to halothane and caffeine; OXPHOS, oxidative phosphorylation
| Respiratory state | Oxygen consumption rate (pmol s−1 mg−1) |
|||
|---|---|---|---|---|
| MHN |
MHS |
MHN vs MHS |
||
| Control vs halothane-exposure (P-value) | Control comparisons (P-value) | |||
| Leak | 0.944 | 0.429 | 0.732 | |
| CI(OXPHOS) | 0.593 | 0.012 | 0.113 | |
| CI+CII(OXPHOS) | 0.789 | 0.005 | 0.071 | |
| CI+CII(ETS) | 0.157 | 0.003 | 0.050 | |
| CII(ETS) | 0.057 | 0.001 | 0.376 | |
| CIV(MAX) |
0.718 |
0.101 |
0.021 |
|
| Respiratory state | Flux control ratio (FCR) | |||
| MHN | MHS | MHN vs MHS | ||
| Control vs halothane-exposure (P-value) |
Control comparisons (P-value) |
|||
| LEAK | 0.753 | 0.362 | 0.074 | |
| CI(OXPHOS) | 0.480 | 0.007 | 0.534 | |
| CI+CII(OXPHOS) | 0.470 | 0.003 | 0.033 | |
| CI+CII(ETS) | ||||
| CII(ETS) | 0.041 | 0.001 | 0.005 | |
| CIV(MAX) |
0.307 |
0.052 |
0.913 |
|
| Respiratory state | FCR differences (halothane-exposed - control) | |||
| Kruskal-Wallis (P-value) | Post hoc (P-value) | |||
| MHN vs MHSh |
MHN vs MHShc |
MHShvs MHShc |
||
| LEAK | 0.349 | |||
| CI(OXPHOS) | 0.209 | |||
| CI+CII(OXPHOS) | 0.043 | 1.000 | 0.036 | 0.390 |
| CI+CII(ETS) | 0.086 | |||
| CII(ETS) | 0.263 | |||
| CIV(MAX) | 0.532 | |||