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. 2019 May 6;97(1):39–53. doi: 10.1111/cge.13553

Figure 2.

Figure 2

Consequences of succinate dehydrogenase (SDH) loss. SDH loss leads to the accumulation of succinate which inhibits a‐ketoglutarate dependent dioxygenases including prolyl‐hydroxylases (PHD), ten–eleven translocation (TET) and jumonji C‐domain‐containing proteins (JmjC) [Colour figure can be viewed at http://wileyonlinelibrary.com]