Figure 2.
Consequences of succinate dehydrogenase (SDH) loss. SDH loss leads to the accumulation of succinate which inhibits a‐ketoglutarate dependent dioxygenases including prolyl‐hydroxylases (PHD), ten–eleven translocation (TET) and jumonji C‐domain‐containing proteins (JmjC) [Colour figure can be viewed at http://wileyonlinelibrary.com]