Table 1.

Phenotyping Probe Substrates and Metrics Used in the Study

Enzyme	Probe Substrate	Phenotyping Metric
CYP1A2	Caffeine 200 mg	Caffeine AUCinf
CYP2C9	Warfarin 10 mg + vitamin K 10 mg	S‐Warfarin AUCinf
CYP2C19	Omeprazole 30 mg	5‐Hydroxy‐omeprazole to omeprazole AUCinf ratio
CYP2D6	Dextromethorphan 30 mg	Dextromethorphan AUCinf Dextromethorphan to dextrorphan molar urinary ratio
CYP3A	Midazolam 5 mg	Midazolam AUCinf