Table 2.

Pediatric outcome of 4 children prenatally exposed to chemotherapy for gastric cancer, included in the INCIP follow‐up study

Case	Gestational age at diagnosis (wk)	Gestational age at delivery (wk)	Age at follow up	Chemotherapy during pregnancy	General outcome	Cardiac outcome	Neurological outcome	Cognitive outcome	Supportive care
8	22	39	4 mo	FOLFOX 6 cycles	Normal growth	No details	No details	No details	No supportive care
9	15	34	18 mo	FOLFOX 7 cycles Radiation exposure: 12 mGya Trastuzumab exposure during first trimester	Normal growth and development	No details	No neurological abnormalities	18 mo: normal cognitive development for his premature age	No supportive care
11	6 (first trimester)	32	15 mo	Carboplatin and paclitaxel 3 cycles	Normal growth and development	No abnormalities	Cerebral palsy left, epilepsy and hemianopia left side	15 mo: normal cognitive development for his premature age	0‐12 mo physiotherapy once a week
			3 years					3 years: normal cognitive development
			6 years					6 years: normal cognitive development
13	30	38	6 mo	FOLFOX 4 cycles	Normal growth and development	No abnormalities	No neurological abnormalities	No details	No supportive care

Note: OVERVIEW of examinations in INCIP follow‐up study.

Pediatric consultation: A general physical examination and neurological assessment performed by a pediatrician.

Cardiac assessment: 12‐lead electrocardiograph (ECG) and a full ECG assessment for structural and functional characteristics was collected by a cardiologist/experienced sonographer.

Cognitive assessment: an age‐adapted test battery for the assessment of intelligence, verbal and non‐verbal memory, attention, working memory and executive functions by an experienced psychologist (Bayley Scales of Infant and Toddler Development, third edition, Child Behavior Checklist, Behavior Rating Inventory of Executive Function—Preschool Version, Wechsler Preschool and Primary Scale of Intelligence, third edition, Subtask of Children's Memory Scale, Subtasks of Amsterdam Neuropsychological Tasks, Behavior Rating Inventory of Executive Function).

^aBelow recommended fetal radiation exposure of 50 mGy.