Table 3.
Literature review: Case reports on chemotherapy for gastric cancer during pregnancy
| Ref. | Number of cases | Patient age (years), AGP, gestational age at diagnosis (wk) | Histology | Stage at diagnosis | Symptoms at diagnosis | Treatment | Period of treatment (gestational weeks) | Complications during pregnancy, Obstetrical outcome, Gestational age at delivery (wk) | Weight at birth (g), neonatal outcome | Maternal outcome (months after delivery) |
|---|---|---|---|---|---|---|---|---|---|---|
| Cift et al, 201111 | Case 1 | 26, A0G2P1, 24 | Poorly differentiated adenocarcinoma with signet ring cell morphology | Stage IV (bilateral adnexal masses) | Abdominal pain, nausea and vomiting | 4 days of 5‐FU (425 mg/m2 and 10 mg/m2 calcium folinate) | 29‐294/7 | Preterm contractions, spontaneous vaginal delivery, 294/7 wk | 930 g, healthy | DOD (2 days) |
| Pacheco et al 201612 | Case 1 | 27, A0G3P2 12 | Poorly differentiated adenocarcinoma with signet ring cell | cT3N3M1 (stage IV) (peritoneal metastasis) | Epigastric pain, weight loss | Palliative chemotherapy (5‐FU [1000/m2] and cisplatin [75 mg/m2] day 1,2,3,4 every 28 d, 4 cycles during pregnancy) | 12‐24 | Preterm contractions, spontaneous vaginal delivery, 26 wk | 850 g, Deceased (0.5 mo) due to respiratory failure | DOD (7 mo) |
| Case 2 | 33, A0G2P1 15 | Poorly differentiated adenocarcinoma with signet ring cell morphology | cT3N0M0 (stage IIA) pT4aN3M0 (stage pIIIC) | Epigastric pain, weight loss | FOLFOX (oxaliplatin 85 mg/m2, leucovor 200 mg/m2, 5‐FU (400 mg/m2 day 1, 600 mg/m2 day 1 and 2) every 14 days), 4 cycles during pregnancy, total radical gastrectomy after delivery, adjuvant chemoradiation | 18‐26 | Preterm contractions, spontaneous vaginal delivery, 36 wk | 3150 g, healthy | Deceased (41 mo) | |
| Kim et al 201613 | Case 1 | 36, AxGxPx, 18 | unknown | Locally advanced stage | unknown | Totally laparoscopic distal gastrectomy followed by FOLFOX, 4 cycles during pregnancy | 28‐33 | No complications, elective delivery 36 wk | healthy | NED (12 mo) |
| Nishie et al 201514 | Case 1 | >30y, AxGxPx, 23 | Poorly differentiated adenocarcinoma, no HER2 overexpression | Stage IV (bilateral adnexal masses, cervical lymph node | Epigastralgi, left cervical lymph node swelling | 2 cycles of Paclitaxel (50 mg/m2) on days 1 and 8 and S1* daily (100 mg/body), Continued Cisplatin and S1 after pregnancy | 24‐334/7 | IUGR and peripheral neuropathy, elective cesarean section, 34 wk | 1442 g, healthy | Progressive disease with meningitis carcinomatosis, DOD (6.3 mo) |
S1*: tegafur (=prodrug of active substance 5‐FU), gimeracil, oteracil.
Abbreviations: APG, Abortion(miscarriage)/Gravidity/Parity; DOD, Dead of disease; IUGR, intrauterine growth restriction; NED, no evidence of disease.