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PfEMP1 presentation on knobs on the IE surface. KAHRP form the base of the knob complex. An average of three PfEMP1 molecules are located at the tip of each knob.58 KAHRP binding to spectrin is necessary for the formation of the spiral structure, but KAHRP itself does not appear to be a component of the spiral.54 PHIST protein may connect to PfEMP1 and the cytoskeleton.56 Redrawn and modified from Cutts et al53
