Table 1.
Guaiac fecal occult blood test (gFOBT) specificity following autologous blood administration (n = 7 per condition) to or pinch biopsies (n = 8 per condition) of the stomach, duodenum, or colon in adult male rhesus macaques
| Experimental group | Stomach | Duodenum | Colon | Negative Control | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 mL | 5 mL | 1 mL | Biopsy | 10 mL | 5 mL | 1 mL | Biopsy | 1 mL | 0.5 mL | 0.1 mL | Biopsy | ||
|
gFOBT sensitivity (% positive) |
7/7 (100%) | 6/7 (86%) | 2/7 (29%) | 2/8 (25%) | 7/7 (100%) | 6/7 (86%) | 2/7 (29%) | 3/8 (38%) | 4/7 (57%) | 4/7 (57%) | 6/7 (86%) | 7/8 (88%) | |
| 95% CI | 65%‐100% | 49%‐99% | 5%‐64% | 4%‐59% | 65%‐100% | 49%‐99% | 5%‐64% | 14%‐69% | 25%‐84% | 25%‐84% | 49%‐99% | 53%‐99% | |
|
gFOBT specificity (% negative) |
9/11 (82%) | ||||||||||||
| 95% CI | 52%‐97% | ||||||||||||
When present in the cage pan, feces were collected for gFOBT every 12 h beginning 24 h and ending 72 h post‐procedure. If at least one positive gFOBT result was obtained, macaques were considered gFOBT‐positive. gFOBT specificity was determined by evaluating negative control animals, in which no procedure was performed prior to fecal collection. Where relevant, sensitivity or specificity is reported with a 95% confidence interval (95% CI).