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. 2019 May 18;40(1):9–26. doi: 10.1002/med.21594

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© 2019 The Authors. Medicinal Research Reviews Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Following detection of a cleft lip and/or palate (CL/P) using prenatal ultrasound screening, cord blood stem cells are isolated upon birth. These stem cells express antifibrotic factors and anti‐inflammatory factors and can be used in tissue engineering strategies in combination with factors targeting inflammation and fibrosis (e.g. anakinra, pirfenidone and nintedanib) within a scaffold during cleft surgery to promote skin and muscle regeneration and function and to inhibit scar formation [Color figure can be viewed at wileyonlinelibrary.com]