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. 2020 Jan 21;10:851. doi: 10.1038/s41598-020-57512-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cereblon gene and protein conservation across different vertebrate species (top) alignment of CRBN CULT-domain coding region and translated protein (bottom). Species affected by typical TE are Homo sapiens (human), Macaca mulatta (Rhesus monkey), Macaca fascicularis (crab-eating monkey), Oryctolagus cuniculus (rabbit), Gallus gallus (chicken) and Danio rerio (zebrafish). The rodents Rattus norvegicus (rat) and Mus musculus (mouse) do not present typical TE, after exposure to thalidomide during embryonic development. Nucleotides (top) and amino acids (bottom) alignment between the eight species studied. Only synonymous mutations are identified in the region. Source: UNIPROT.