Table 1.

Literature main findings for CRL4^CRBN-thalidomide interaction and induced protein effect.

Pubmed ID	Protein Interaction	IMiD tested in the study	Is the mechanism IMiD dependent?	IMiD-protein interaction effect*
27142104	AGO2	lenalidomide	yes	alters expression.
26990986	GS	none	no
27294876	CD147	none, Thal, Len, Pom	no	competition for CRBN binding reduces expression
27294876	MCT1	none, Thal, Len, Pom	no	competition for CRBN binding reduces expression
26021757	CLC1	none	no
19295130	DDA1	none	no
24292623	IKZF1	Thal, Len, Pom	yes	induced degradation
24292623	IKZF3	Thal, Len, Pom	yes	induced degradation
27468689	TAB2	none	no
27468689	TRAF6	none	no
25043012	MEIS2	lenalidomide	no	block MEIS2 binding to CRBN
21232561	AMPKA1	none	no
23026050	PSMB4	none	no
27601648	RABGEF1	lenalidomide	no	prevents association to CRBN
31591562	TP63	thalidomide	yes	neosubstrate of thalidomide-CRBN
30067223	SALL4	Thal, Len, Pom	yes	thalidomide-CRBN induced degradation (C2H2 motif)

Thal: thalidomide; Len: lenalidomide; Pom: pomalidomide; *differential mechanism in presence or absence of the IMiD.