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. 2020 Jan 21;10:815. doi: 10.1038/s41598-020-57784-3

Figure 2.

Figure 2

Febuxostat improved the glucose tolerance and insulin sensitivity of mice fed the CL diet. (a) Glucose tolerance test (GTT; 2 g/kg body weight) was performed after 12 weeks of feeding (n = 7–8 mice per group). Bar graphs represent area under the curve (AUC) calculations. (b) Blood glucose and (c) plasma insulin levels of mice fasted for 16 h or fed ad libitum (n = 6–7 mice per group). (d) Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated from fasting plasma glucose and insulin concentrations (n = 6–7 mice per group). Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01 vs. NC; #P < 0.05, ##P < 0.01, vs. CL; †P < 0.05 vs. CL + Feb.