Table 1.

Metabolic parameters after 18 weeks of feeding.

	NC	CL	CL + Feb	CL + Allo
Epididymal fat (% of BW)	3.9 ± 0.3	5.0 ± 0.2*	4.5 ± 0.2	4.5 ± 0.2
Liver weight (% of BW)	4.1 ± 0.1	5.9 ± 0.3**	5.0 ± 0.2**#	5.6 ± 0.1**
Plasma TG (mg/dL)	142.6 ± 9.7	85.5 ± 5.1*	76.6 ± 6.5*	70.3 ± 4.7*
Plasma TC (mg/dL)	208.8 ± 27.4	382.1 ± 29.8*	380.0 ± 13.1*	415.6 ± 11.9*
Plasma FFAs (mmol/L)	1.51 ± 0.04	1.26 ± 0.05*	1.14 ± 0.04*	1.10 ± 0.07*
Plasma ALT (IU/L)	6.1 ± 1.9	95.5 ± 11.0**	29.3 ± 6.1##	29.2 ± 2.7##
Plasma AST (IU/L)	25.9 ± 5.2	105.3 ± 20.9**	62.6 ± 5.1$	73.2 ± 5.5*

Shown are epididymal fat pad weight, liver weight, plasma levels of triglycerides (TG), total cholesterol (TC), free fatty acids (FFAs), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in mice fed the indicated diets for 18 weeks. Plasma samples were collected from the mice fasted for 16 h. Measurements are reported as mean ± SEM (n = 7–8/group). *P < 0.05, **P < 0.01 vs. NC; ^$P < 0.1, ^#P < 0.05, ^##P < 0.01 vs. CL. NC, normal chow; CL, high-fat, -cholesterol, and -cholate diet; CL + Feb, CL diet containing 0.001% febuxostat; CL + Allo, CL diet containing 0.003% allopurinol.