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. 2020 Jan 21;11:419. doi: 10.1038/s41467-020-14299-9

Fig. 5. Modeling the role of S-HDAg acetylation and BRF chromatin remodelers in HDV viral replication.

Fig. 5

The K72acXXR75 sequence in the S-HDAg protein mimics histone H3 K14acXXR17 motif and interacts with the bromodomain (BRD) of BAZ2B. The recruitment the BRF chromatin remodelers to the HDV RNP empowers the virus to hijack the host transcriptional machinery for the replication of its RNA genome. The proposed model is based upon the RIP experiments shown in Figs. 2c, 2d, and 4c; the in vitro pull-down assays shown in Fig. 2f and Supplementary Fig. 4c; the co-immunoprecipitation experiments shown in Fig. 3f and the PHHs infection experiments with wt HDV and R75A recombinant HDV shown in Fig. 4b.