Table 5.

Clinical values of blood enantiomeric proportions obtained in the Control vs. MCI or Dementia groups (selected participants).

Group	Enantiomeric proportion	Sensitivity (%)	Specificity (%)	AUC	95% CI	p-value	Cut-off
Control vs. MCI	D-Pro, %D	57	87	0.71	0.639–0.789	<0.001	0.41
	D-Ser, %D	58	57	0.60	0.519–0.681	0.016	0.91
	D-Ala, %D	68	55	0.67	0.589–0.743	<0.001	0.31
	D-Pro × D-Ser, %D2	70	84	0.80	0.723–0.877	<0.001	0.30
	D-Pro × D-Ala, %D2	74	58	0.72	0.642–0.792	<0.001	0.10
	D-Ser × D-Ala, %D2	68	58	0.67	0.598–0.752	<0.001	0.26
	D-Pro × D-Ser × D-Ala, %D3	65	68	0.73	0.653–0.802	<0.001	0.10
	D-Pro × D-Ser/D-Ala, %D	57	53	0.55	0.465–0.637	0.246	0.82
Control vs. Dementia	D-Pro, %D	67	87	0.72	0.457–0.987	0.100	0.45
	D-Ser, %D	83	58	0.67	0.381–0.955	0.251	0.94
	D-Ala, %D	67	68	0.68	0.429–0.924	0.163	0.41
	D-Pro × D-Ser, %D2	67	90	0.73	0.448–1.003	0.112	0.50
	D-Pro × D-Ala, %D2	83	80	0.77	0.543–0.996	0.020	0.16
	D-Ser × D-Ala, %D2	83	78	0.73	0.471–0.995	0.080	0.45
	D-Pro × D-Ser × D-Ala, %D3	83	80	0.80	0.553–1.042	0.026	0.15
	D-Pro × D-Ser/D-Ala, %D	67	68	0.62	0.361–0.878	0.365	1.19

Selected participants: Control (N = 60, MMSE: 30), MCI (N = 149, MMSE: 26–21), Dementia (N = 6, MMSE: 20–0).