Table 2.
Univariable analyses to predict pathological outcomes in patients who underwent radical prostatectomy.
| Cancer stage ≥ pT3 | Gleason score ≥ 7 | High-risk disease | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | |
| Age | 1.01 (0.93, 1.11) | 0.754 | 1.18 (1.02, 1.38) | 0.031 | 1.01 (0.92, 1.10) | 0.866 |
| Prostate volume | 0.99 (0.97, 1.01) | 0.428 | 0.98 (0.96, 1.01) | 0.170 | 0.99 (0.96, 1.01) | 0.274 |
| Biopsy GS ≥7 | 5.91 (1.59, 22.06) | 0.008 | 2.24 (0.59, 8.44) | 0.233 | 5.17 (1.75, 15.27) | 0.003 |
| tPSA | 1.07 (1.01, 1.14) | 0.028 | 1.02 (0.93, 1.13) | 0.614 | 1.07 (1.01, 1.14) | 0.030 |
| fPSA | 1.42 (0.92, 2.18) | 0.109 | 0.86 (0.48, 1.54) | 0.606 | 1.41 (0.92, 2.16) | 0.117 |
| %fPSA | 0.95 (0.87, 1.03) | 0.199 | 0.91 (0.81, 1.01) | 0.078 | 0.94 (0.87, 1.02) | 0.157 |
| p2PSA | 1.03 (1.01, 1.06) | 0.005 | 1.01 (0.98, 1.03) | 0.702 | 1.03 (1.01, 1.06) | 0.007 |
| %p2PSA | 1.79 (1.08, 2.95) | 0.023 | 1.38 (0.61, 3.10) | 0.438 | 1.62 (1.01, 2.61) | 0.047 |
| PHI | 1.02 (1.01, 1.04) | 0.002 | 1.01 (0.99, 1.03) | 0.452 | 1.02 (1.01, 1.04) | 0.003 |
| Upgraded GS sum | Positive surgical margin | Seminal vesical invasion | ||||
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | |
| Age | 1.06 (0.96, 1.18) | 0.213 | 1.00 (0.92, 1.09) | 0.964 | 0.99 (0.87, 1.13) | 0.874 |
| Prostate volume | 1.01 (0.99, 1.03) | 0.291 | 0.98 (0.96, 1.01) | 0.182 | 1.00 (0.96, 1.03) | 0.839 |
| Biopsy GS ≥7 | 0.00 (0.00, 0.03) | <0.001 | 1.55 (0.64, 3.76) | 0.333 | 2.42 (0.49, 12.00) | 0.278 |
| tPSA | 1.01 (0.96, 1.07) | 0.654 | 1.11 (1.03, 1.18) | 0.004 | 1.07 (1.00, 1.15) | 0.055 |
| fPSA | 1.23 (0.80, 1.89) | 0.337 | 1.34 (0.87, 2.05) | 0.183 | 1.36 (0.80, 2.32) | 0.250 |
| %fPSA | 1.00 (0.92, 1.09) | 0.987 | 0.94 (0.86, 1.01) | 0.098 | 0.92 (0.81, 1.06) | 0.247 |
| p2PSA | 1.01 (0.99, 1.02) | 0.421 | 1.04 (1.01, 1.07) | 0.006 | 1.02 (1.00, 1.03) | 0.085 |
| %p2PSA | 0.96 (0.62, 1.50) | 0.861 | 2.06 (1.18, 3.60) | 0.011 | 1.55 (0.95, 2.55) | 0.080 |
| PHI | 1.00 (0.99, 1.01) | 0.858 | 1.03 (1.01, 1.05) | 0.001 | 1.01 (1.00, 1.03) | 0.014 |
CI: confidence interval; GS: Gleason score; OR: odds ratio; PHI: Prostate Health Index; PSA: prostate specific antigen; tPSA: total PSA; fPSA: free PSA; %fPSA = percentage of free to total PSA; p2PSA: [−2]pro PSA; %p2PSA = (p2PSA/fPSA × 1000) × 100.