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. 2020 Jan 21;10:787. doi: 10.1038/s41598-019-57409-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network analysis for miRNA/mRNA interaction. (A) The Venn diagrams represent number of unique and common L. vannamei mRNAs and miRNAs that are expressed in response to VP_AHPND infection and following the NLHS and NH treatments. The differentially expressed genes (DEGs) and miRNAs (DEMs) were identified based on RNA-Seq data and small RNA-Seq data, respectively. The number of DEGs or DEMs identified through the normalization of genes or miRNAs expressed by L. vannamei hemocytes infected with VP_AHPND (NLHS-VP) at 6 and 24 hpi (6 NLHS-VP and 24 NLHS-VP) to that of 0 hpi (0 NLHS-VP) is shown in the red circle. The blue circle represents the number of DEGs or DEMs derived from VP_AHPND-infected L. vannamei hemocyte controls (NH-VP) at 6 and 24 hpi (6 NH-VP and 24 NH-VP) with that of 0 hpi (0 NH-VP). (B) The miRNA/mRNA negative correlation network based on the predicted miRNA target function. The upper panel is the miRNA/mRNA network of up-regulated miRNAs (blue circle) and down-regulated genes (yellow circle), whereas the lower panel is the miRNA/mRNA network of down-regulated miRNAs (yellow circle) and up-regulated genes (blue circle). (C) The miRNA/mRNA negative correlation network of selected unique isotigs. The upper panel is the miRNA/mRNA network of up-regulated miRNAs (blue circle) and down-regulated genes (yellow circle), whereas the lower panel is the miRNA/mRNA network of down-regulated miRNAs (yellow circle) and up-regulated genes (blue circle). The circular nodes represent mRNAs and miRNAs. The degree of connectivity, which represents the number of genes regulated by a given miRNA, is indicated by the size of the node.