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. 2020 Jan 21;10:879. doi: 10.1038/s41598-020-57795-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between genome wide schizophrenia PRS and pharmagenic enrichment scores in the ASRB cohort. (a) Pairwise univariate correlation between each of the PES and total PRS. Scale represents strength of relationship in the positive or negative direction. Kernel density estimation of the distribution of total schizophrenia PRS in the entire ASRB cohort, stratified by the number of PES profiles in the top quartile (b) and decile (c) respectively. These plotted distributions range from individuals with no elevated PES, denoted zero on the scale, to those with six elevated PES, that is, a score of six represents an individual with six PES categories in the top quartile or decile of the ASRB cohort. (d) Distribution of total PRS between ASRB participants with at least one PES in the 99th percentile of the cohort (grey, N = 55) or without (orange, N = 621). Black dashed line represents the mean PRS_Total for the cohort with a top percentile PES (right) and without (left).