Table 2.
The top enriched drug target for each pharmagenic enrichment score pathway with at least three interacting genes after multiple testing correction.
| Pathway | Top Drug | Overlap | Adjusted P-value | ATC Code |
|---|---|---|---|---|
| NOS1 | Milnacipran | 5 | 1.63 × 10−7 | Other antidepressants |
| GABA | Temazepam | 14 | 0 | Benzodiazepine derivatives |
| Insulin | Clodronic acid | 3 | 1.97 × 10−3 | Bisphosphonates |
| HIF-2 | Ascorbic acid (Vitamin C) | 3 | 4.61 × 10−2 | Ascorbic acid (Vitamin C) |
| Acetylcholine | Nicotine | 11 | 0 | Drugs used in nicotine dependence |
| Folate | Tetrahydrofolic acid | 11 | 0 | Folic acid and derivatives |
Most significantly associated drug after multiple testing correction was selected, when corrected P values were equal, the drug with the highest geneset overlap was selected, very small P values are denoted as zero by WebGestalt. Overlap refers to the number of genes targeted by the drug in the candidate pathway.