Table 2.

The top enriched drug target for each pharmagenic enrichment score pathway with at least three interacting genes after multiple testing correction.

Pathway	Top Drug	Overlap	Adjusted P-value	ATC Code
NOS1	Milnacipran	5	1.63 × 10−7	Other antidepressants
GABA	Temazepam	14	0	Benzodiazepine derivatives
Insulin	Clodronic acid	3	1.97 × 10−3	Bisphosphonates
HIF-2	Ascorbic acid (Vitamin C)	3	4.61 × 10−2	Ascorbic acid (Vitamin C)
Acetylcholine	Nicotine	11	0	Drugs used in nicotine dependence
Folate	Tetrahydrofolic acid	11	0	Folic acid and derivatives

Most significantly associated drug after multiple testing correction was selected, when corrected P values were equal, the drug with the highest geneset overlap was selected, very small P values are denoted as zero by WebGestalt. Overlap refers to the number of genes targeted by the drug in the candidate pathway.