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. 2020 Jan 21;10:777. doi: 10.1038/s41598-019-57275-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The characteristics of wild-type (WT), FcGRIIb−/− and pristane mice with 30 days of dextran sulfate solution (DSS) or water control drinking water (started at 24-wk-old; symptomatic lupus) as determined by serum anti-dsDNA Ig (A), renal injury (serum creatinine; Cr) (B), proteinuria (spot urine/creatinine) (C), systemic inflammation (serum IL-6) (D), and leaky-gut as determined by spontaneous serum (1→3)-β-D-glucan (BG) (E) and spontaneous endotoxemia (F) were demonstrated (n = 7–10 per group). *p < 0.05, ^#p < 0.05 vs. WT DSS.