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. 2020 Jan 21;10:777. doi: 10.1038/s41598-019-57275-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The characteristics of wild-type (WT), FcGRIIb−/− and pristane mice with 60 days of dextran sulfate solution (DSS) (started at 8-wk-old; asymptomatic lupus) or water control drinking water as determined by renal injury (serum creatinine; Cr) (A), proteinuria (spot urine/creatinine) (B), systemic inflammation (serum IL-6) (C), and leaky-gut as determined by spontaneous serum (1→3)-β-D-glucan (BG) (D) and spontaneous endotoxemia (E) were demonstrated. In addition, these characteristics of mice with the protocol of co-housing (plus fecal gavage) by feces of 40-wk-old WT or 40-wk-old FcGRIIb−/− (F–J) and the comparison between DSS versus the co-housing (plus fecal gavage) (K–O) were indicated (n = 7–10 per group). *p < 0.05, ^#p < 0.05 vs. WT DSS.