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. 2020 Jan 21;10:812. doi: 10.1038/s41598-020-57733-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of pilocarpine and pentylenetetrazol on neural activity and cerebral blood flow (CBF) in a representative anesthetized WT mouse as measured by simultaneous EEG and LSI. (A) Raw EEG trace demonstrating induction of SE by pilocarpine (pilo; 280 mg/kg, i.p.) and pentylenetetrazol (PTZ; 120 mg/kg, i.p.). Green arrows denote injection times; blue numbers denote acquisition time of each numbered LSI image in panel B. (B) LSI images of CBF at single time points. (C) RMS power and flux (CBF as measured by LSI) overlay demonstrates a period of severe IHR (orange bar). Green arrows and blue numbers carried over from panel A. (D) Analysis of late-SE CBF (Flux) and RMS power at the time period denoted by the orange bar in panel C reveal a negative correlation.