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. 2020 Jan 21;10:839. doi: 10.1038/s41598-020-57619-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The TCA cycle. All metabolites in the TCA cycle were decreased or depleted in the infected group. In particular, four metabolites downstream of 2-OG (2-OG, succinyl CoA, succinic acid, and fumaric acid) fell below measurable limits in the infected group. The metabolic pathway from isocitric acid to 2-OG was strongly inhibited in the infected group according to the depletion of NAD⁺ from accelerated β-oxidation. The value of each metabolites is the concentration relative to the control.