Table 3.
Kinetic evaluation of covalent‐allosteric Akt ligands with Akt2.
|
|
Akt2wt |
||
|---|---|---|---|
|
# |
K i [nM] |
k inact [103 min−1] |
k inact/K i [103 μM−1 s−1] |
|
borussertib |
30±5 |
34±6 |
19±1 |
|
16 b |
57±6 |
30±5 |
9±1 |
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