Figure 7.

Effect of various inhibitors on GSK‐induced ATP release from GP bladder strips. A, Carbenoxolone (100 μM; connexin/pannexin channel blocker) significantly reduces GSK‐induced (n = 9). B, Brefeldin A (10 μM; vesicular transport inhibitor) has no effect on GSK‐induced ATP release. C, NPPB (100 μM; inhibits Ca²⁺‐sensitive chloride currents) has no effect on GSK‐induced ATP release (n = 6). D: Genistein (100 μM; selective protein tyrosine kinase inhibitor) significantly reduces GSK‐stimulated ATP release (n = 8). Median [25%, 75%], Wilcoxon's. Control: 282 ± 72 pmoles/g tissue/min