Figure 4.

Receiver operating characteristic curve using duration played to classify chronic traumatic encephalopathy (CTE) status. Thresholds of duration played that corresponded to negative and positive likelihood ratios (LR−, LR+, respectively) closest to 0.1 and 10 were 4.5 years and 14.5 years, respectively. Diagnostic tests with these likelihood ratios may produce sizable and often conclusive shifts from pre‐ to post‐test probability.42 CTE classification sensitivity and specificity were maximized together at approximately 11 years played. AUC = area under the curve.