Table 4.
Univariate and multivariate Cox regression analysis of overall survival (OS) and melanoma‐specific survival (MSS) in men
| OS | MSS | |||
|---|---|---|---|---|
| Univariable [HR (95% CI, P‐value)] | Multivariable [HR (95% CI, P‐value)]a | Univariable [HR (95% CI, P‐value)] | Multivariable [HR (95% CI, P‐value)]b | |
| Inherited MC1R variants (yes) | 1·17 (0·84–1·63, 0·347) | 1·26 (0·89–1·79, 0·185) | 0·98 (0·65–1·47, 0·917) | 1·09 (0·71–1·67, 0·685) |
| Age (continuous) | 1·05 (1·04–1·06, < 0·001) | 1·04 (1·03–1·05, < 0·001) | 1·02 (1·01–1·03, 0·001) | 1·02 (1·00–1·03, 0·011) |
| Breslow index (continuous) | 1·18 (1·14–1·22, < 0·001) | 1·15 (1·10–1·20, < 0·001) | 1·21 (1·17–1·25, < 0·001) | 1·17 (1·12–1·23, < 0·001) |
| Ulceration (present) | 2·75 (2·02–3·75, < 0·001) | 1·41 (0·97–2·06, 0·074) | 3·55 (2·40–5·25, < 0·001) | 1·80 (1·13–2·88, 0·013) |
| Mitotic index (continuous) | 1·06 (1·03–1·08, < 0·001) | – | 1·08 (1·05–1·11, < 0·001) | – |
| Naevus total count (< 50) | – | – | – | – |
| 51–100 | 0·47 (0·28–0·77, 0·003) | – | 0·49 (0·26–0·93, 0·030) | – |
| ≥ 101 | 0·65 (0·40–1·06, 0·086) | – | 0·59 (0·30–1·15, 0·119) | – |
HR, hazard ratio; CI, confidence interval. aMultivariable analysis based on 605 men and 165 events (C‐index = 0·758). bMultivariable analysis based on 605 men and 103 events (C‐index = 0·758)