Figure 1.

Synthesis of PHPMAC₄₁‐PHPMA₁₈₀ via RAFT aqueous dispersion polymerization of HPMA at 70 °C. Uniquely, this thermoresponsive diblock copolymer exhibits a double thermal transition enabling either spheres, worms or vesicles to be obtained at a fixed PHPMA DP, simply by varying the aqueous solution temperature from 4 °C to 50 °C (see TEM images and schematic cartoon).