Table 2.
Cox regression analyses on the influence of rs56163822 SNP (G/T), rs35724 (G/C or C/C), and other parameters on any (further) hepatic decompensation (A) in the overall cohort and (B) on first decompensation in CPS‐A patients during follow up. P values <0.05 are written in bold
| (A) Overall cohort, n = 402 | (B) CPS‐A patients, n = 221 | |||||
|---|---|---|---|---|---|---|
| Risk factors for hepatic decompensation | aHR | 95% CI | P value | aHR | 95% CI | P value |
| Age, per 10 years | 1.325 | 1.148–1.528 | < 0.001 | 1.214 | 0.954–1.544 | 0.115 |
| Male gender (vs female) | 1.357 | 0.947–1.944 | 0.096 | 1.840 | 0.972–3.482 | 0.061 |
| HVPG, per mmHg | 1.047 | 1.024–1.070 | < 0.001 | 1.070 | 1.021–1.123 | 0.005 |
| MELD, per point | 1.010 | 0.962–1.059 | 0.697 | 1.030 | 0.924–1.149 | 0.588 |
| Albumin, per g/dL | 0.929 | 0.903–0.955 | < 0.001 | 0.938 | 0.880–0.999 | 0.048 |
| rs56163822 SNP (G/T vs wild type) | 0.773 | 0.339–1.760 | 0.540 | 0.708 | 0.220–2.279 | 0.562 |
| rs35724 SNP (G/C or C/C vs wild type) | 0.830 | 0.602–1.145 | 0.256 | 0.625 | 0.374–1.044 | 0.072 |
P values <0.05 are written inbold.
95% CI, 95% confidence interval; aHR, adjusted hazard ratio; CPS, Child–Pugh stage; HVPG, hepatic venous pressure gradient; MELD, model of end‐stage liver disease; SNP, single nucleotide polymorphism.