Table 4.

Cox regression analyses on the influence of rs56163822 (G/T), rs35724 (G/C or C/C) genotypes, and other parameters on liver‐related transplant‐free mortality during follow up (A) in patients with clinically significant portal hypertension (CSPH; HVPG ≥ 10 mmHg) and (B) in patients with HVPG ≥ 16 mmHg. P values <0.05 are written in bold

	(A) CSPH, n = 313			(B) HVPG ≥ 16 mmHg, n = 198
Liver‐related mortality	aHR	95% CI	P value	aHR	95% CI	P value
Age, per 10 years	1.379	1.113–1.709	0.003	1.355	1.050–1.748	0.019
Male gender (vs female)	2.463	1.374–4.414	0.002	2.240	1.144–4.383	0.019
HVPG, per mmHg	1.017	0.974–1.062	0.443	1.003	0.940–1.070	0.939
MELD, per point	0.963	0.895–1.037	0.320	.917	0.837–1.005	0.064
Albumin, per g/dL	0.900	0.865–0.937	< 0.001	0.902	0.855–0.951	< 0.001
rs56163822 SNP (G/T vs wild type)	1.044	0.374–2.915	0.935	1.500	0.514–4.378	0.459
rs35724 SNP (G/C or C/C vs wild type)	0.547	0.346–0.864	0.010	0.519	0.307–0.878	0.014

P values <0.05 are written inbold.

95% CI, 95% confidence interval; aHR, adjusted hazard ratio; CSPH, clinically significant portal hypertension; HVPG, hepatic venous pressure gradient; HVPG, hepatic venous pressure gradient; MELD, model of end‐stage liver disease; SNP, single nucleotide polymorphism.