Table 3.

Association of Annual Hospitalization Rate with Global Cognitive Decline, before and after Adjustment for Neuropathologic Burden

Model Term	Model A, n = 526a			Model B, n = 491b
	Estimate	SE	p	Estimate	SE	p
Timec	−0.088	0.009	<0.001	−0.088	0.009	<0.001
Hospitalization rate	−0.109	0.035	0.002	−0.127	0.036	<0.001
Hospitalization rate × time	−0.042	0.012	<0.001	−0.040	0.013	0.002
Aged	−0.028	0.004	<0.001	−0.027	0.004	<0.001
Sex	−0.140	0.045	0.002	−0.161	0.047	<0.001
Education	0.048	0.007	<0.001	0.047	0.008	<0.001
Time × age	−0.003	0.001	0.007	−0.003	0.001	0.040
Amyloid burden				−0.002	0.005	0.72
Tau tangle density				−0.014	0.003	<0.001
Gross infarcts				−0.019	0.044	0.67
Microinfarcts				−0.033	0.045	0.47
Neocortical Lewy bodies				−0.024	0.062	0.70
Hippocampal sclerosis				−0.222	0.082	0.007
TDP‐43				0.011	0.048	0.82

^aEstimated from mixed‐effects model.

^bEstimated from mixed‐effects model with nonmissing data for all 7 neuropathological measures.

^cTime = time since baseline.

^dAge = age at baseline.

SE = standard error; TDP‐43 = transactive response DNA binding protein 43 kDa.