Table 4.

Modification of Association of Hospitalization Rate with Global Cognitive Decline by Neuropathologic Markers^a

Interaction Term	Estimate	SE	p
Hospitalization × amyloid burden × time	0.004	0.003	0.12
Hospitalization × tau tangle density × time	−0.007	0.002	0.002
Hospitalization × gross infarcts × time	−0.038	0.028	0.17
Hospitalization × microinfarcts × time	0.024	0.028	0.39
Hospitalization × neocortical Lewy bodies × time	−0.117	0.042	0.005
Hospitalization × hippocampal sclerosis × time	0.059	0.069	0.39
Hospitalization × TDP‐43 × time	−0.016	0.030	0.60

^aEstimated from a mixed‐effects model including terms for age at baseline, sex, education, time (since baseline), the interaction of age with time, hospitalization rate, the interaction of hospitalization rate with time, each neuropathology, the interactions of each neuropathological marker with time, the interactions of each neuropathological marker with hospitalization rate, and the 3‐way interactions of each neuropathological marker with hospitalization rate and time in all participants with nonmissing data for all 7 neuropathological measures (n = 491).

SE = standard error; TDP‐43 = transactive response DNA binding protein 43 kDa.